Bioengineers can embedded soft, stretchable electronics into the tiny clusters to create “cyborg” islet organoids. These can mimic the pancreas, sensing glucose levels and releasing hormones. This could help building replacement cells for people with type 1 diabetes.

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Massively parallel reporter assays across five cell types identify thousands of causal, noncoding regulatory variants among 220,000 loci, revealing diverse regulatory mechanisms shaping complex traits and disease.